Selection Table of Functional Groups

Chiral Center

Functional Group

Remark

Normal
Phase

Reversed
Phase

Aromatic

C=O

-OH

|
-N-

-COOH

 

Amino Acids and Their Derivatives

Carboxylic Acids

Primary Amines & Amides (-NH2, -CONH2, or -SO2NH2)

Yes

Yes

Yes

Yes

-

Linear

F.02

F.25

Cyclic

F.03

F.26

Yes

Yes

Yes

-

-

Linear

F.04

F.27a

Cyclic

-

F.27b

Yes

Yes

-

Yes

-

Linear

F.06/07

F.28

Cyclic

F.08/09

F.29/30/31

Yes

Yes

-

-

-

Linear

F.10/11

F.32

Cyclic

F.12

F33/34

Yes

-

Yes

Yes

-

Linear

F.13

F.35

Cyclic

F.14

F.36a

Yes

-

Yes

-

-

Linear

F.15/16

F.36b

Cyclic

F.17

F.37

Yes

-

-

Yes

-

Linear

F.18

F.38

Cyclic

F.19

F.39

Yes

-

-

-

-

Linear

F.20a

-

Cyclic

F.20b

F.40a

-

Yes

Yes

Yes

-

Linear

-

F.40b

Cyclic

F.21a

-

-

Yes

Yes

-

-

Linear

F.21b

-

Cyclic

F.21c

F.41a

-

Yes

-

Yes

-

Linear

-

-

Cyclic

F.22a

F.41b

-

Yes

-

-

-

Linear

F.22b

-

Cyclic

F.23

F.42a

-

-

Yes

-

-

Linear

F.24a

F.42b

Cyclic

F.24b

F.43a

-

-

-

-

-

Linear

-

-

Cyclic

-

F.43b

-

-

-

Yes

Yes

-

F.44/45

F.46/47/48

-

-

-

-

Yes

-

F.49/50

F.51/52

-

-

-

Yes

-

-

F.53/54

Metal Containing Compounds

-

-

-

-

-

-

F.55

P

-

-

-

-

-

-

F.56

S, N

-

-

-

-

-

-

F.57

Axial and Planar Dissymmetric Compounds

-

-

-

-

-

-

F.58/59

Chiral Center

Aromatic

C=O

-OH

|
-N-

-COOH

Remark

Normal
Phase

Reversed
Phase

Functional Group