Application of Chiral Columns for Achiral Compound Separations

Daicel is the global leader in chiral separations, and is at the forefront of polysaccharide-based chiral stationary phase (CSP) development. We have extensive experience utilizing these CSPs to perform chiral separations on both high performance liquid chromatography (HPLC) and super-critical fluid chromatography (SFC). More recently, it has been discovered that these CSPs perform well in achiral separations as well, such as for the separation of diastereomers or structural isomers. This has become clearer to us through our wealth of internal separations experience, while concurrently being recognized and acknowledged amongst our external users. Because of this, there are now many opportunities for users to request separations for both chiral and achiral compounds under our analytical services and our outsourced preparative business.

Proposals from Daicel

  • If the target separation cannot be achieved with an achiral ODS-type column, consider the use of a chiral column.
  • The orthogonality of the separation selectivity is considered to be high between ODS columns and chiral columns. Therefore, it can also be recommended as a "sub-analysis method" to ensure purity in parallel analyses with different modes.
  • Characteristic separation behavior in chiral columns may allow for high productivity in column preparations.

On this page, the application of achiral compound separations are summarized. Additionally, the retention mechanism of the polysaccharide-based CSPs is discussed, which can be inferred from the results of force field calculations done by Professor Ueda of Yokohama National University. The following contents introduce the amazing separation capabilities of polysaccharide-based CSPs:

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