JAPANESE
Chiral Columns
Protein-based Chiral HPLC Columns
CHIRALPAK® AGP
| Product name | Product type | Internal Diameter(mm) |
Length (mm) | Particle size (µm) | P/N |
|---|---|---|---|---|---|
| CHIRALPAK® AGP | Analytical column | 4 | 50 | 5 | 30712 |
| Analytical column | 4 | 100 | 5 | 30713 | |
| Analytical column | 4 | 150 | 5 | 30714 | |
| Analytical column | 3 | 50 | 5 | 30782 | |
| Analytical column | 3 | 100 | 5 | 30783 | |
| Analytical column | 3 | 150 | 5 | 30784 | |
| Analytical column | 2.1 | 50 | 5 | 30792 | |
| Analytical column | 2.1 | 100 | 5 | 30793 | |
| Analytical column | 2.1 | 150 | 5 | 30794 | |
| Semi-prep | 10 | 100 | 5 | 30733 | |
| Semi-prep | 10 | 150 | 5 | 30734 | |
| Guard cartridge ( x 2 ) | 2.1 | 10 | 5 | 30791 | |
| Guard cartridge ( x 2 ) | 3 | 10 | 5 | 30781 | |
| Guard cartridge ( x 2 ) | 4 | 10 | 5 | 30711 | |
| Guard cartridge holder ( for AGP/CBH/HSA) | - | 00081 |
CHIRALPAK® CBH
| Product name | Product type | Internal Diameter(mm) |
Length (mm) | Particle size (µm) | P/N |
|---|---|---|---|---|---|
| CHIRALPAK® CBH | Analytical column | 4 | 50 | 5 | 33712 |
| Analytical column | 4 | 100 | 5 | 33713 | |
| Analytical column | 4 | 150 | 5 | 33714 | |
| Analytical column | 3 | 50 | 5 | 33782 | |
| Analytical column | 3 | 100 | 5 | 33783 | |
| Analytical column | 3 | 150 | 5 | 33784 | |
| Analytical column | 2 | 50 | 5 | 33792 | |
| Analytical column | 2 | 100 | 5 | 33793 | |
| Analytical column | 2 | 150 | 5 | 33794 | |
| Semi-prep | 10 | 100 | 5 | 33733 | |
| Semi-prep | 10 | 150 | 5 | 33734 | |
| Guard cartridge ( x 2 ) | 2 | 10 | 5 | 33791 | |
| Guard cartridge ( x 2 ) | 3 | 10 | 5 | 33781 | |
| Guard cartridge ( x 2 ) | 4 | 10 | 5 | 33711 | |
| Guard cartridge holder ( for AGP/CBH/HSA) | - | 00081 |
CHIRALPAK® HSA
| Product name | Product type | Internal Diameter(mm) |
Length (mm) | Particle size (µm) | P/N |
|---|---|---|---|---|---|
| CHIRALPAK® HSA | Analytical column | 4 | 50 | 5 | 34712 |
| Analytical column | 4 | 100 | 5 | 34713 | |
| Analytical column | 4 | 150 | 5 | 34714 | |
| Analytical column | 3 | 50 | 5 | 34782 | |
| Analytical column | 3 | 100 | 5 | 34783 | |
| Analytical column | 3 | 150 | 5 | 34784 | |
| Analytical column | 2 | 50 | 5 | 34792 | |
| Analytical column | 2 | 100 | 5 | 34793 | |
| Analytical column | 2 | 150 | 5 | 34794 | |
| Semi-prep | 10 | 100 | 5 | 34733 | |
| Semi-prep | 10 | 150 | 5 | 34734 | |
| Guard cartridge ( x 2 ) | 2 | 10 | 5 | 34791 | |
| Guard cartridge ( x 2 ) | 3 | 10 | 5 | 34781 | |
| Guard cartridge ( x 2 ) | 4 | 10 | 5 | 34711 | |
| Guard cartridge holder ( for AGP/CBH/HSA) | - | 00081 |
Feature
CHIRALPAK® AGP has extremely broad applicability for the separation of chiral drugs.
- Basic compounds
- : CHIRALPAK® AGP、CHIRALPAK® CBH
- Acids, Non-protolytic compounds
- : CHIRALPAK® AGP、CHIRALPAK® HSA
- CHIRALPAK® AGP has extremely broad applicability for the separation of chiral drugs.
- The protein-based columns function entirely in the reversed-phase chromatographic mode, using buffers with low organic modifier content and at moderate pH values.
- Possibility to dynamically improve enantioseparation.
CHIRALPAK AGP® has extremely broad applicability for the separation of chiral drugs.
○The chiral selector is alpha1-acid glycoprotein (AGP). This very stable protein is immobilized onto spherical 5 micrometer silica particles.
The CHIRALPAK® AGP column separates enantiomers of an extremely broad range of drug compounds.
・Amine (primary, secondary, and tertiary)
・Acids (strong and weak)
・Nonprotolytes (amides, esters, alchohols, sulfoxides, etc.)
CHIRALPAK CBH
○The chiral selector is Cellobiohydrolase (CBH). This is a stable enzyme, which has been immobilized onto 5 micrometer spherical silica particles.
○CHIRALPAK® CBH is used for the separation of enantiomers of basic drugs from many compound classes. CHIRALPAK® CBH separates preferentially compounds containing one or more basic nitrogen's together with one or more hydrogen accepting or hydrogen donating groups (alcohol, phenol, carbonyl, amide, ether, sulphoxide, ester etc.).
CHIRALPAK HSA
○The chiral selector is human serum albumin (HSA). The protein has been immobilized onto spherical 5 micrometer particles.
○CHIRALPAK® HSA is especially suited for the separation of weak and strong acids, zwitterionic and nonprotolytic compounds.
